Application References


Image Processing
Breitbach, CJ et al. 2007. Targeted Inflammation During Oncolytic Virus Therapy Severely Compromises Tumor Blood Flow. J Am Soc Gene Ther 15(9):1686-93. Centre for Cancer Therapeutics, Ottawa Health Research Institute, Ottawa, Ontario, Canada.

Fan, J et al. 2007. Saikosaponin-d attenuates the development of liver fibrosis by preventing hepatocyte injury. Biochem. Cell Biol. 85: 189-195. Faculty of Pharmacy, University of Manitoba, Winnipeg, Canada.

Kiraly, MA et al. 2007. Attenuation of type 2 diabetes mellitus in the male Zucker diabetic fatty rat: the effects of stress and non-volitional exercise. Metabolism Clinical and Experimental 56: 732-744. Dept of Physiology; Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada.

Krajewska, M et al. 2007. Claudin-I immunohistochemistry for distinguishing malignant from benign epithelial lesions of prostate. The Prostate 67: 907-910. Burnham Institute for Medical Research, La Jolla, CA.

Miller, SL et al. 2007. Nek3 kinase regulates prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells. Oncogene 26: 4668-4678. Department of Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, NY.

Pham, Nhu-An et al. 2007. Quantitative image analysis of immunohistochemical stains using a CMYK color model. Diagnostic Pathology 2:8 Division of Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, University Health Network, Toronto, Canada.

Soltani, N et al. 2007. In vivo expression of GLP-1/lgG-Fc fusion protein enhances betacell mass and protects against streptozotocininduced diabetes. Gene Therapy 14, 981-988. Department of Medicine, University of Toronto, Ontario, Canada.

Wenzel, P et al. 2007. Rb is critical in a mammalian tissue stem cell population. Genes & Development 21:85-97. Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, College of Medicine, The Ohio State University, Columbus, Ohio.

Wiederschain, D et al. 2007. Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis. Molecular and Cellular Biology 27(13): 4968-4979. Oncology Research and Discovery Technologies, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts.

Wong, HL et al. 2006. In vivo evaluation of a new polymer-lipid hybrid nanoparticle (PLN) formulation of doxorubicin in a murine solid tumor model. European Journal of Pharmaceutics Biopharmaceutics 65: 300-308. Grad Dept of Pharmaceutical Sciences, University of Toronto, Ontario, Canada.

Yang, X et al. 2007. Differences in risk factors for breast cancer molecular subtypes in a population-based study. Cancer Epidemiol Biomarkers Prev 16(3): 439-443. Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland.

Drug Delivery
Wong, HL et al. 2007. In vivo evaluation of a new polymer-lipid hybrid nanoparticle (PLN) formulation of doxorubicin in a murine solid tumor model. European Journal of Pharmaceutics and Biopharmaceutics 65: 300- 308. Graduate Department of Pharmaceutical Sciences, University of Toronto, Ontario, Canada.

Education
Goldberg, H and Dintzis, R. 2007. The positive impact of team-based virtual microscopy on student learning in physiology and histology. Advan Physiol Educ 31: 261- 265. The Johns Hopkins School of Medicine, The Johns Hopkins University, Baltimore, Maryland.

Ho, J et al. 2006. Use of whole slide imaging in surgical pathology quality assurance: design and pilot validation studies. Human Pathology. Center for Pathology Informatics, Dept of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Lundin, M et al. 2004. Virtual microscopy. Journal Clinical Pathology 57: 1250-1251. Biomedical Informatics Group, Department of Oncology, University of Helsinki, Finland. Marchevsy, M et al. 2006. The use of virtual microscopy for proficiency testing in gynecologic cytopathology. Arch Pathol Lab Med 130: 349-355. Dept of Pathology and Lab Medicine, Cedars-Sinai Medical Center, Los Angeles, California.

Rojo, MG et al. 2006. Critical comparison of 31 commercially available digital slide systems in pathology. International Journal of Surgical Pathology 14: 285. Pathology Department, Hospital General de Ciudad Real, Spain.

Uhlen, M et al. 2005. A human protein atlas for normal and cancer tissues based on antibody proteomics. Molecular & Cellular Proteomics 4: 1920-1932. Dept of Biotechnology, AlbaNova Univ Center, Royal Institute of Technology, Stockholm, Sweden.

General Applications
Lundin, M et al. 2004. Virtual microscopy. Journal Clinical Pathology 57: 1250-1251. Biomedical Informatics Group, Department of Oncology, University of Helsinki, Finland.

Linking Pathology with Radiology
Slaymaker, M et al. 2006. A prototype infrastructure for the secure aggregation of imaging and pathology data for colorectal cancer care. IEEE Computer-Based Medical Systems. Oxford University Computing Laboratory, Oxford, United Kindgom.

Nanotechnology
Wong, HL et al. 2007. In vivo evaluation of a new polymer-lipid hybrid nanoparticle (PLN) formulation of doxorubicin in a murine solid tumor model. European Journal of Pharmaceutics and Biopharmaceutics 65: 300- 308. Graduate Department of Pharmaceutical Sciences, University of Toronto, Ontario, Canada.

Pathologist Adoption
Mea, VD et al. 2006. User attitudes in analyzing digital slides in a quality control test bed: A preliminary study. Computer Methods and Programs in Biomedicine 82: 177-186. Dept of Math and Computer Science, University of Udine, Udine, Italy.

Platform Comparisons
Rojo, MG et al. 2006. Critical comparison of 31 commercially available digital slide systems in pathology. International Journal of Surgical Pathology 14: 285. Pathology Department, Hospital General de Ciudad Real, Spain.imaging technologies in toxicologic pathology: an overview. Toxicologic Pathology 34:815-826. Drug Safety Evaluation, Sanofi-Aventis, Bridgewater, New Jersey.

Proficiency Testing
Marchevsy, M et al. 2006. The use of virtual microscopy for proficiency testing in gynecologic cytopathology. Arch Pathol Lab Med 130: 349-355. Dept of Pathology and Lab Medicine, Cedars-Sinai Medical Center, Los Angeles, California.

Stewart, J et al. 2007. Virtual microscopy for cytology proficiency testing. Cancer Cytopathology 111(4): 203-209. Dept of Pathology and Lab Med, University of Wisconsin School of Med and Public Health, Madison, Wisconsin.

Quality Assurance Testing
Ho, J et al. 2006. Use of whole slide imaging in surgical pathology quality assurance: design and pilot validation studies. Human Pathology. Center for Pathology Informatics, Dept of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Ramirez, N et al. 2007. Utilizing virtual microscopy for quality control review. Disease Markers 23: 459-466. Columbus Children’s Research Institute, Center for Childhood Cancer, Columbus, Ohio.

Tissue Microarrays
Bjorling, E et al. 2007. A web-based tool for in silico biomarker discovery based on tissuespecific protein profiles in normal and cancer tissues. Molecular & Cellular Proteomics. School of Biotechnology, AlbaNova Univ Center, Royal Institute of Tech, Stockholm, Sweden.

Conway, C et al. 2006. The development and validation of the Virtual Tissue Matrix, a software application that facilitates the review of tissue microarrays on line. BMC Bioinformatics 7: 256. Med Informatics Group, School of Biotechnology, Dublin City Univ, Dublin, Ireland.

Liu, J et al. 2006. Integrin-linked kinase inhibitor KP-392 demonstrates clinical benefits in an orthotopic human non-small cell lung cancer model. J Thorac Oncol 1:771-779. Div of Thoracic Surgery, Toronto General Hospital, University Health Network and the Dept of Surgery and Institute of Med Science, Faculty of Medicine, University of Toronto, Ontario, Canada.

Luciano, F et al. 2007. Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma. Blood 109(9): 3849-3855. Burnham Institute for Medical Research, La Jolla, California.

Miller, SL et al. 2007. Nek3 kinase regulates prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells. Oncogene 26: 4668-4678. Dept of Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, New York.

Rabinovich, A et al. 2006. Framework for parsing, visualizing and scoring tissue microarray images. IEEE Transactions on Info Tech in Biomedicine 10(2): 209-219. Dept of Computer Science and Engineering, UCSD, La Jolla, California.

Sauter, G et al. 2003. Tissue microarrays in drug discovery. Nature 2: 962-972. Institut of Pathology, Univ of Basel, Basel, Switzerland. Stewart, J et al. 2006. Comparison of annexin II, p63 and AMACR immunoreactivity in prostatic tissue: a tissue microarray study. Journal Clinical Pathology. 60: 773-780. Dept of Pathology, Toronto General Hospital, Toronto, Ontario, Canada.

Stromberg, S et al. 2007. A high-throughput strategy for protein profiling in cell microarrays using automated image analysis. Proteomics 7: 2142-2150. Dept of Genetics and Pathology, Rudbeck Lab, Uppsala Univ, Uppsala, Sweden.

Whiteford, C et al. 2007. Credentialing preclinical pediatric xenograft models using gene expression and tissue microarray analysis. Cancer Research 67(1): 32-40. Oncogemomics section, NIH, Bethesda, Maryland.

Yang, XR et al. 2007. Hormonal markers in breast cancer: coexpression, relationship with pathologic characteristics, and risk factor associations in a population-based study. Cancer Research 67(21): 10608-10617. Division of Cancer Epidemiology & Genetics, NIH, Bethesda, Maryland.

Yoshimoto, M et al. 2007. FISH analysis of 107 prostate cancers show that PTEN genomic deletion is associated with poor clinical outcome. British Journal of Cancer 1-8. Division of Applied Molecular Oncology, Ontario Cancer Institute, Princess Margaret Hospital , Toronto, Ontario, Canada.

Toxicologic Pathology
Dee, F. 2006. Virtual microscopy for comparative pathology. Toxicologic Pathology 34(7):966-967. Professor of Pathology Univ of Iowa, Iowa City, Iowa.

McCullough, B et al. 2004. Digital microscopy imaging and new approaches in toxicologic pathology. Toxicologic Pathology 32(2): 49- 58. Aventis, Drug Safety Evaluation, Bridgewater, New Jersey.

Ying, X and Monticello,T. 2006. Modern imaging technologies in toxicologic pathology: an overview. Toxicologic Pathology 34:815- 826. Drug Safety Evaluation, sanofi-aventis, Bridgewater, New Jersey.

Virtual Tissue Database
Conway, C et al. 2006. The development and validation of the Virtual Tissue Matrix, a software application that facilitates the review of tissue microarrays on line. BMC Bioinformatics 7: 256. Med Informatics Group, School of Biotechnology, Dublin City Univ, Dublin, Ireland.

Mikula, S et al. 2007. Internet-enabled highresolution brian mapping and virtual microscopy. NeuroImage 35:9-15. Center for Neuroscience University of California, Davis, California.

Uhlen, Mathias et al. 2005. A human protein atlas for normal and cancer tissues based on antibody proteomics. Molecular & Cellular Proteomics 4:1920-1932. Dept of Biotechnology, AlbaNova Univ Center, Royal Institute of Technology, Stockholm, Sweden.

* Aperio products are FDA cleared for specific clinical applications, and are intended for research use for other applications.